Dibutyltin Dichloride-d18

Base Information

• Chemical Name: Dibutyltin Dichloride-d18
• CAS No.: 683-18-1
• Molecular Formula: C8H18Cl2Sn
• Molecular Weight: 303.847
• Hs Code.: 29310095
• Mol file: 683-18-1.mol

Synonyms:Dibutyltin Dichloride-d18;dibutyltin(2+);dichloride;Di-n-butyldichlorostannane;AKOS025146494;D0223

Chemical Property of Dibutyltin Dichloride-d18

Chemical Property:

• Appearance/Colour: White Crystalline Liquid
• Vapor Pressure: 0.0016 hPa (25 °C)
• Melting Point: 39 °C
• Refractive Index: 1.4991
• Boiling Point: 275.3 °C at 760 mmHg
• Flash Point: 107.8 °C
• PSA: 0.00000
• Density: 1.4
• LogP: 4.50640
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Solubility.: 0.32g/l
• Water Solubility.: 320 mg/L, hydrolises in hot water
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 303.980759
• Heavy Atom Count: 11
• Complexity: 37.8

Purity/Quality:

99% ^*data from raw suppliers

Dibutyltin Dichloride >97.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T; N
• Hazard Codes: T,N,C,T+
• Statements: 25-34-51/53-63-23/24/25-68-50/53-48/25-26-21-61-60
• Safety Statements: 26-36/37/39-45-61-38-28A-60-53

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC[Sn+2]CCCC.[Cl-].[Cl-]
• Uses: Dibutyltin dichloride is used as an organotin intermediate. It serves as heat and light stabilizer for polyvinyl chloride plastics. It is also used in the preparation of methyl 2-(methoxycarbonylmethyl)-5-iodobenzene by reacting with 2,5-diiodobenzoic acid. It acts as an esterification catalyst and a veterinary vermicide and tapeworm remedy. Further, it is used as ion exchange agent, process regulators and processing aids.

Technology Process of Dibutyltin Dichloride-d18

There total 96 articles about Dibutyltin Dichloride-d18 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tin (7440-31-5) + n-Butyl chloride (109-69-3) → dibutyltin chloride (683-18-1) + tributyltin chloride (1461-22-9)

Guidance literature:

With catalyst: dicyclohexyl-18-crown-6/n-C₄H₉I; In N,N-dimethyl-formamide; 120°C; 24 h; excess KI;; analyzed by GLC;;

DOI:10.1016/0022-328X(87)80275-9

Reference yield: 97.9%

tetra-n-butyltin(IV) (1461-25-2) + tin(IV) chloride (7646-78-8) → dibutyltin chloride (683-18-1)

Guidance literature:

With aluminium trichloride; molar ratio of Sn(C4H9)4:SnCl4 = 0.65:0.70, 150°C;

Reference yield: 96.0%

tetra-n-butyltin(IV) (1461-25-2) + tin(IV) chloride (7646-78-8) → Trichlorbutylstannan (1118-46-3) + dibutyltin chloride (683-18-1)

Guidance literature:

molar ratio of Sn(C4H9)4:SnCl4 = 1:3, 8 h, 203°C;

upstream raw materials:

tetra-n-butyltin(IV)

n-Butyl chloride

n-butylmagnesium iodide

divinyldibutyltin

Downstream raw materials:

dibutyldimethoxytin

tetra-n-butyltin(IV)

divinyldibutyltin

diallyldibutyltin

Refernces

Organotin(IV) 4-nitrophenylethanoates: Synthesis, structural characteristics and intercalative mode of interaction with DNA

10.1016/j.jorganchem.2009.06.036

The research investigates the synthesis, structural properties, and DNA-binding behavior of four new organotin(IV) carboxylates, namely [Bu2SnL2] (1), [Et2SnL2] (2), [Bu3SnL]n (3), and [Me3SnL]n (4), where L represents the 4-nitrophenylethanoates ligand. The purpose of this study is to provide insights into the drug-DNA interaction mechanism and potential drug design applications, particularly in the context of anticancer activity. The researchers synthesized these compounds using organotin(IV) precursors and characterized them through elemental analysis, FT-IR, multinuclear NMR, and X-ray single crystal analysis. Dibutyltin(IV) dichloride was used as a precursor for the synthesis of complex 1. The study found that the ligand coordinated to the organotin moiety via the COO group, with different coordination modes observed in the complexes. Cyclic voltammetry was employed to evaluate the electrochemical, kinetic, and thermodynamic parameters of these complexes interacting with DNA, revealing diffusion-controlled processes and binding constants indicating the order of binding strength as 2 < 1 < 4 < 3. Additionally, compounds 1 and 2 demonstrated anticancer activity against prostate cancer cell lines (PC-3), consistent with their voltammetric behavior. The research concludes that these organotin(IV) derivatives show potential as chemotherapeutic agents due to their intercalative interaction with DNA and their anticancer activity, suggesting further exploration for drug development.