(E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide

Base Information

• Chemical Name: (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide
• CAS No.: 141750-56-3
• Molecular Formula: C₂₃H₂₁FN₂O₂
• Molecular Weight: 376.43

Synonyms:(E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide

Chemical Property of (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide

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Technology Process of (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide

There total 4 articles about (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanesulfonyl chloride (124-63-0) + N-methoxy-N-methyl3-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-2-yl>-3-hydroxypropanamide (155849-96-0) → (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide (141750-56-3)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield: 80.0%

N-methoxy-N-methyl3-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-2-yl>-3-hydroxypropanamide (155849-96-0) → (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide (141750-56-3)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; for 3h; Heating;

DOI:10.1246/bcsj.68.350

Reference yield:

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-acrylic acid (222306-21-0) → (E)-3-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-N-methoxy-N-methyl-acrylamide (141750-56-3)

Guidance literature:

With pivaloyl chloride; triethylamine; In dichloromethane; for 21.8333h;

upstream raw materials:

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate

2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline

N-methoxy-N-methyl3-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-2-yl>-3-hydroxypropanamide

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

(4R)-4,7,7-trimethyl-3-exo-(1-naphthyl)bicyclo<2.2.1>heptan-2-exo-yl (E)-7-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>-3,5-dioxo-6-heptenoate

(S)-(E)-7-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dioxo-hept-6-enoic acid phenylethyl amide

(E)-7-[2-cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-3,5-dioxo-hept-6-enoic acid ethyl ester

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