N,N-Dimethyldodecanamide

Base Information

• Chemical Name: N,N-Dimethyldodecanamide
• CAS No.: 3007-53-2
• Molecular Formula: C14H29NO
• Molecular Weight: 227.39
• Hs Code.: 2924199090
• European Community (EC) Number: 221-117-5
• NSC Number: 76600
• UNII: 04BJ5OT1PA
• DSSTox Substance ID: DTXSID20880881
• Nikkaji Number: J12.880E
• Wikidata: Q27247641
• Mol file: 3007-53-2.mol

Synonyms:N,N-Dimethyldodecanamide;3007-53-2;N,N-Dimethyllauramide;Hallcomid M 12;N,N-Dimethyldodecamide;Lauryl N,N-dimethylamide;DODECANAMIDE, N,N-DIMETHYL-;NN-Dimethyllauramide;n,n-dimethyl lauramide;EINECS 221-117-5;NSC 76600;UNII-04BJ5OT1PA;BRN 1769950;04BJ5OT1PA;AI3-26661;NSC-76600;EC 221-117-5;NN-Dimethyldodecanamide;N,N-dimethyl Dodecanamide;Lauric acid N,N-dimethylamide;Hallcomid M-12;Dodecanamide,N-dimethyl-;AGNIQUE AMD 12;SCHEMBL160049;IPL 11;1-Dodecanamide, N,N-dimethyl-;DTXSID20880881;CHEBI:189156;WLN: 11VN1&1;NSC76600;MFCD00026554;AKOS009158400;HY-W127444;Lauric acid N,N-dimethylamide, ~95%;LS-63418;CS-0185676;FT-0655276;A820177;W-111715;Q27247641

Chemical Property of N,N-Dimethyldodecanamide

Chemical Property:

• Appearance/Colour: Colorless transparent liquid
• Vapor Pressure: 0.00289mmHg at 25°C
• Refractive Index: 1.447
• Boiling Point: 284.9 °C at 760 mmHg
• PKA: -0.43±0.70(Predicted)
• Flash Point: 106 °C
• PSA: 20.31000
• Density: 0.861 g/cm³
• LogP: 3.99550
• Storage Temp.: 2-8°C
• Water Solubility.: 28.02mg/L at 20℃
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 10
• Exact Mass: 227.224914549
• Heavy Atom Count: 16
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

N,N-DIMETHYLDODECANAMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCC(=O)N(C)C

Technology Process of N,N-Dimethyldodecanamide

There total 13 articles about N,N-Dimethyldodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

lauric acid (143-07-7) + benzylamine (100-46-9) → N,N-dimethyldodecanamide (3007-53-2) + benzamide of lauric acid (78172-96-0)

Guidance literature:

With potassium hydroxide; bis(o-nitrophenyl)phenylphosphonate; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; other amines; multistep reaction;

DOI:10.1246/cl.1981.285

Reference yield: 96.0%

lauric acid (143-07-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyldodecanamide (3007-53-2)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 1h; Sealed tube;

Reference yield: 92.0%

n-dodecanoyl chloride (112-16-3) + dimethyl amine (124-40-3) → N,N-dimethyldodecanamide (3007-53-2)

Guidance literature:

In benzene; at 20 ℃;

DOI:10.1021/jo00188a021

upstream raw materials:

n-dodecanoyl chloride

dimethyl amine

1-undecene

formamide

Downstream raw materials:

N,N-dimethylaminododecane

(Z)-3-(Methoxy-phenylsulfanyl-methyl)-tetradec-2-en-1-ol

(Z)-3-(Methoxy-phenylsulfanyl-methyl)-tetradec-2-enoic acid methyl ester

1-dodecyl alcohol

Refernces

• 1、 Bi, Xiaojing,Li, Junchen,Shi, Enxue,Li, Yu,Liu, Ying,Wang, Hongmei,Xiao, Junhua. "POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides". supporting information. p. 236 - 240. Retrieved 2019/04/25.
• 2、 -. "FeCl3 catalyzed amide compound synthesis method". Paragraph 0075; 0076; 0077; 0078; 0079. . Retrieved 2018/03/28.