2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Base Information

• Chemical Name: 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
• CAS No.: 120853-21-6
• Molecular Formula: C₄₅H₅₃Cl₂N₅O₉Si₂
• Molecular Weight: 935.021

Synonyms:2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Chemical Property of 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

There total 4 articles about 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine (120853-19-2) → 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N2-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine (120853-21-6)

Guidance literature:

With pyridine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jo00274a041

Reference yield:

2'-O-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-guanosine (71481-37-3) → 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N2-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine (120853-21-6)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / Ambient temperature

2: 1.) 1-methylpyrrolidine / 1.) CH₂Cl₂, RT, 45 min, 2.) RT, 15 h

3: 93 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With 1-Methylpyrrolidine; pyridine; dmap; triethylamine; In dichloromethane;

DOI:10.1021/jo00274a041

Reference yield:

3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine (69304-44-5) → 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N2-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine (120853-21-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / Ambient temperature

3: 1.) 1-methylpyrrolidine / 1.) CH₂Cl₂, RT, 45 min, 2.) RT, 15 h

4: 93 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With 1-Methylpyrrolidine; pyridine; dmap; triethylamine; In dichloromethane;

DOI:10.1021/jo00274a041

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

2'-O-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-guanosine

3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine

Downstream raw materials:

2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 120853-21-6 2'-O-acetyl-6-O-(3,5-dichlorophen-1-yl)-N²-<<(9-fluorenylmethyl)oxy>carbonyl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send