tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate
CAS No.:1186081-49-1
Molecular Formula:C₂₂H₂₉N₃O₅S
Molecular Weight:447.555
Hs Code.:

Synonyms:tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1186081-71-9
tert-butyl 4-[(5-chloropyrazin-2-yl)methoxy]piperidine-1-carboxylate

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1186081-49-1
tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; isopropyl alcohol; toluene; at 20 - 120 ℃; Inert atmosphere;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1186081-49-1
tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 18 h / Reflux

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol; toluene / 20 - 120 °C / Inert atmosphere

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; isopropyl alcohol; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 105985-21-5
2-chloro-5-pyrazinylmethyl chloride

: 1186081-49-1
tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 18 h / Reflux

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol; toluene / 20 - 120 °C / Inert atmosphere

With sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; isopropyl alcohol; toluene; 2.1: Suzuki Coupling;