(1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol

Base Information

• Chemical Name: (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol
• CAS No.: 146499-02-7
• Molecular Formula: C₁₉H₂₈O₂
• Molecular Weight: 288.43

Synonyms:(1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol

Chemical Property of (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol

Chemical Property:

Purity/Quality:

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Technology Process of (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol

There total 3 articles about (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1R,4aS,8S,8aS)-8-(2'-hydroxymethyl-5'-methoxyphenyl)-8-methyldecahydronaphthalen-1-ol → (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol (146499-02-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate;

DOI:10.1071/CH9930593

Reference yield:

(1'S,4a'S,8a'S)-4-methoxy-2-(1'-methyl-8'-oxodecahydronaphthalen-1'-yl)benzaldehyde (150763-52-3) → (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol (146499-02-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaBH₄ / methanol

2: 84 percent / H₂ / Pd/C / ethyl acetate

With sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1071/CH9930593

Reference yield:

methyl magnesium iodide (917-64-6) + (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydronaphthalen-1'-yl 2-oxophenylacetate (146499-04-9) → (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydro-1-naphthalenol (146499-02-7) + (1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydronaphthalen-1'-yl (R)-2-hydroxy-2-phenylpropanoate

Guidance literature:

In diethyl ether; at 0 ℃; for 0.666667h; Product distribution;

DOI:10.1016/S0040-4020(01)80228-3

upstream raw materials:

methyl magnesium iodide

(1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydronaphthalen-1'-yl 2-oxophenylacetate

(1'S,4a'S,8a'S)-4-methoxy-2-(1'-methyl-8'-oxodecahydronaphthalen-1'-yl)benzaldehyde

Downstream raw materials:

(1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydronaphthalen-1'-yl 2-oxophenylacetate

(1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydronaphthalen-1'-yl 3-oxobutanoate

(1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydronaphthalen-1'-yl prop-2-enoate

(1'R,4a'S,8'S,8a'S)-8'-(5''-methoxy-2''-methylphenyl)-8'-methyldecahydronaphthalen-1'-yl (Z)-3-acetamido-2-butenoate

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