2-AMINO-4-(4-METHOXY-PHENYL)-5,6,7,8-TETRAHYDRO-QUINOLINE-3-CARBONITRILE

Base Information

• Chemical Name: 2-AMINO-4-(4-METHOXY-PHENYL)-5,6,7,8-TETRAHYDRO-QUINOLINE-3-CARBONITRILE
• CAS No.: 74873-46-4
• Molecular Formula: C₁₇H₁₇N₃O
• Molecular Weight: 279.341
• Mol file: 74873-46-4.mol

Synonyms:2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

Chemical Property of 2-AMINO-4-(4-METHOXY-PHENYL)-5,6,7,8-TETRAHYDRO-QUINOLINE-3-CARBONITRILE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-AMINO-4-(4-METHOXYPHENYL)-5,6,7,8-TETRAHYDROQUINOLINE-3-CARBONITRILE 95.00% ^*data from reagent suppliers

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Technology Process of 2-AMINO-4-(4-METHOXY-PHENYL)-5,6,7,8-TETRAHYDRO-QUINOLINE-3-CARBONITRILE

There total 3 articles about 2-AMINO-4-(4-METHOXY-PHENYL)-5,6,7,8-TETRAHYDRO-QUINOLINE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → 2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (74873-46-4)

Guidance literature:

With ammonium acetate; In ethanol; at 20 ℃; for 3h; Green chemistry;

DOI:10.1016/j.crci.2015.09.002

Reference yield: 69.0%

2-(4-methoxyphenylmethylene)malononitrile (2826-26-8) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (74873-46-4)

Guidance literature:

With ammonium acetate; In 1,2-dichloro-benzene; for 0.0583333h; Irradiation;

DOI:10.1039/a708521d

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (74873-46-4)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / ethanol / 1 h / 80 °C

2: ammonium acetate / benzene / 10 h / 100 °C

With piperidine; ammonium acetate; In ethanol; benzene;

DOI:10.1007/s11030-018-9897-1

upstream raw materials:

2-(4-methoxyphenylmethylene)malononitrile

cyclohexanone

4-methoxy-benzaldehyde

malononitrile

Downstream raw materials:

2-(pyridin-3-yl)-5-(4-methoxyphenyl)-6,7,8,9-tetrahydropyrimidino[4,5-b]quinolin-4-amine

2-amino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydroquinoline-3-carboxamide

4-chloro-5-(4-methoxyphenyl)-6,7,8,9-tetrahydro-[1,2,3]-triazino[4,5-b]-quinoline

2-ethoxymethyleneamino-4-(4-methoxyphenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile

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