N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester

Base Information

• Chemical Name: N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester
• CAS No.: 1349193-23-2
• Molecular Formula: C₃₂H₄₄N₈O₁₀
• Molecular Weight: 700.749

Synonyms:N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester

Chemical Property of N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester

There total 8 articles about N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

{2-[2-(2-azidoethoxy)ethoxy]ethyl}carbamic acid tert-butyl ester (950683-55-3) + N-[N4-(benzyloxycarbonyl)cytosin-1-ylacetyl]-N-(propyn-3-yl)glycine ethyl ester (1349193-20-9) → N-[N1-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N4-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester (1349193-23-2)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; tert-butyl alcohol; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2011.09.124

Reference yield:

2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol (6338-55-2) → N-[N1-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N4-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester (1349193-23-2)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / methanol / 3 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 48 h / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.tet.2011.09.124

Reference yield:

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate (430430-57-2) → N-[N1-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N4-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester (1349193-23-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / dichloromethane; water; tert-butyl alcohol / 48 h / 20 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/j.tet.2011.09.124

upstream raw materials:

2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl methanesulfonate

{2-[2-(2-azidoethoxy)ethoxy]ethyl}carbamic acid tert-butyl ester

N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]-N-(propyn-3-yl)glycine ethyl ester

8-dibenzylamino-3,6-dioxaoctanoic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1349193-23-2 N-[N₁-(8-tert-butoxycarbonylamino-3,6-dioxaoct-1-yl)-1,2,3-triazol-4-yl]methyl-N-[N₄-(benzyloxycarbonyl)cytosin-1-ylacetyl]glycine ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send