(R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

Base Information

Chemical Name:(R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate
CAS No.:1378928-92-7
Molecular Formula:C₂₄H₄₀N₄O₆
Molecular Weight:480.605
Hs Code.:

Synonyms:(R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

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Technology Process of (R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

There total 1 articles about (R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1151451-77-2
4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)benzaldehyde

: 13518-40-6,75898-43-0,104944-18-5
t-butyl D-valinate hydrochloride

: 1378928-92-7
(R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃; for 42h; Inert atmosphere; Molecular sieve;
DOI:10.1021/jm300199g

Reference yield: 92.0%

: 1378928-92-7
(R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 1378928-93-8
(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

Guidance literature:: With pyridine; at 60 ℃; for 18h;
DOI:10.1021/jm300199g

Reference yield:

: 1378928-92-7
(R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

: 1151451-90-9
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 18 h / 60 °C

2: hydrogenchloride / dichloromethane / 0 °C

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300199g