(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Base Information

Chemical Name:(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide
CAS No.:1151451-90-9
Molecular Formula:C₂₇H₃₉N₅O₉S
Molecular Weight:609.701
Hs Code.:

Synonyms:(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Suppliers and Price of (R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

There total 7 articles about (R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1378928-94-9
(2R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methyl-N-((tetrahydro-2H-pyran-2-yl)oxy)butanamide

: 1151451-90-9
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1.5h;
DOI:10.1021/jm300199g

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 1151451-90-9
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 18 h / 60 °C

2: hydrogenchloride / dichloromethane / 0 °C

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300199g

Reference yield:

: 1151451-77-2
4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)benzaldehyde

: 1151451-90-9
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 42 h / 20 °C / Inert atmosphere; Molecular sieve

2: pyridine / 18 h / 60 °C

3: hydrogenchloride / dichloromethane / 0 °C

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300199g