(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

Base Information

Chemical Name:(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate
CAS No.:1378928-93-8
Molecular Formula:C₃₁H₄₆N₄O₉S
Molecular Weight:650.794
Hs Code.:

Synonyms:(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

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Chemical Property of (R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

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Technology Process of (R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

There total 4 articles about (R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1378928-92-7
(R)-tert-butyl 2-((4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)amino)-3-methylbutanoate

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 1378928-93-8
(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

Guidance literature:: With pyridine; at 60 ℃; for 18h;
DOI:10.1021/jm300199g

Reference yield: 66.0%

: 1151451-83-0
C₁₅H₂₂BrN₃O₄

: 161315-62-4
N-[(4-methoxyphenyl)sulfonyl]-D-valine tert-butyl ester

: 1378928-93-8
(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm300199g

Reference yield:

: 1151451-77-2
4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)benzaldehyde

: 1378928-93-8
(R)-tert-butyl 2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 42 h / 20 °C / Inert atmosphere; Molecular sieve

2: pyridine / 18 h / 60 °C

With pyridine; sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane;
DOI:10.1021/jm300199g