(R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Base Information

Chemical Name:(R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide
CAS No.:1378928-95-0
Molecular Formula:C₄₀H₆₂FN₅O₁₄S
Molecular Weight:888.022
Hs Code.:

(R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

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Chemical Property of (R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

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Technology Process of (R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

There total 11 articles about (R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1378928-87-0
1-fluoro-3,6,9,12,15-pentaoxaoctadec-17-yne

: 1151451-90-9
(R)-2-(N-(4-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

: 1378928-95-0
(R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/jm300199g

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 1378928-95-0
(R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 18 h / 60 °C

2: hydrogenchloride / dichloromethane / 0 °C

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h / 20 °C

5: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 5 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; copper(ll) sulfate pentahydrate; benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300199g

Reference yield:

: 13518-40-6,75898-43-0,104944-18-5
t-butyl D-valinate hydrochloride

: 1378928-95-0
(R)-2-(N-(4-(2-(2-(2-(2-(4-(16-fluoro-2,5,8,11,14-pentaoxahexadecyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)benzyl)-4-methoxyphenylsulfonamido)-N-hydroxy-3-methylbutanamide

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine

2: potassium carbonate / N,N-dimethyl-formamide

3: hydrogenchloride / dichloromethane / 0 °C

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 1.5 h / 20 °C

6: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; N,N-dimethyl-formamide / 5 h / 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; copper(ll) sulfate pentahydrate; potassium carbonate; benzotriazol-1-ol; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm300199g