(4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide

Base Information

Chemical Name:(4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide
CAS No.:928211-66-9
Molecular Formula:C₃₂H₄₅ClN₆O₈S
Molecular Weight:709.264
Hs Code.:

Synonyms:(4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide

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Chemical Property of (4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide

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Technology Process of (4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide

There total 10 articles about (4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 4-chlorobenzylsulfonyl-(D)-Ser-N-Me-Ala-(4-hydroxyguanidinobenzyl)amide

: 3282-30-2
pivaloyl chloride

: 75-98-9
Trimethylacetic acid

: 928211-66-9
(4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

: 928211-73-8
(4-chlorobenzylsulfonyl)-D-Ser(O-tBu)-Cl

: 928211-66-9
(4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane

1.2: 20 °C / Cooling with ice

2.1: methyl-phenyl-thioether; trifluoroacetic acid / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol

3.2: 1.5 h / 0 °C

4.1: sodium acetate / ethanol / 20 °C

5.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 20 °C / Cooling with ice

6.1: 1-methyl-pyrrolidin-2-one / 20 °C

With methyl-phenyl-thioether; hydroxylamine hydrochloride; hydrogen; sodium acetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane;

Reference yield:

: 928211-71-6
N-Me-Ala-4-nitrobenzylamide hydrochloride

: 928211-66-9
(4-chlorobenzylsulfonyl)-D-Ser(CO-t-Bu)-N-Me-Ala-4-(N-tert-butylcarbonyloxyguanidino)benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane

1.2: 20 °C / Cooling with ice

2.1: methyl-phenyl-thioether; trifluoroacetic acid / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol

3.2: 1.5 h / 0 °C

4.1: sodium acetate / ethanol / 20 °C

5.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 20 °C / Cooling with ice

6.1: 1-methyl-pyrrolidin-2-one / 20 °C

With methyl-phenyl-thioether; hydroxylamine hydrochloride; hydrogen; sodium acetate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane;