6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

Base Information

Chemical Name:6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde
CAS No.:258283-81-7
Molecular Formula:C₁₈H₁₈O₇
Molecular Weight:346.337
Hs Code.:

Synonyms:6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

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Chemical Property of 6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

Chemical Property:

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Technology Process of 6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

There total 1 articles about 6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 64490-45-5
2-iodo-3,4,5-trimethoxybenzyl alcohol

: 94838-88-7
2-formyl-4,5-(methylenedioxy)benzeneboronic acid

: 258283-81-7
6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane;
DOI:10.1021/ja9930059

Reference yield:

: 258283-81-7
6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

: 258283-80-6
6-[2,3,4-trimethoxy-6-(2-oxo-2,5-dihydro-furan-3-ylmethyl)-phenyl]-benzo[1,3]dioxole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: LiBr / acetone

3: 83 percent / Pd₂(dba)3; trifurylphosphine / 1,2-dimethoxy-ethane / 80 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifuran-2-yl-phosphane; triethylamine; lithium bromide; In 1,2-dimethoxyethane; dichloromethane; acetone; 1: mesylation / 2: Substitution / 3: Condensation;
DOI:10.1021/ja9930059

Reference yield:

: 258283-81-7
6-(6-hydroxymethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

: 258283-82-8
6-(6-bromomethyl-2,3,4-trimethoxy-phenyl)-benzo[1,3]dioxole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: LiBr / acetone

With triethylamine; lithium bromide; In dichloromethane; acetone; 1: mesylation / 2: Substitution;
DOI:10.1021/ja9930059