4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile

Base Information

Chemical Name:4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile
CAS No.:1126771-27-4
Molecular Formula:C₁₈H₁₄BrClN₄
Molecular Weight:401.693
Hs Code.:

Synonyms:4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile

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Chemical Property of 4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile

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Technology Process of 4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile

There total 1 articles about 4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1126779-39-2
2-bromo-5-(chloromethyl)pyridine hydrochloride

: 1126779-37-0
2-chloro-4-(1H-pyrazol-4-yl)benzonitrile

: 1126771-27-4
4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Cooling with ice;

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1126771-27-4
4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile

: 1126773-26-9
5-{[4-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-1-yl]methyl}pyridine-2-carbonitrile

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 5h; Inert atmosphere;

Reference yield:

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1126771-27-4
4-{1-[(6-bromopyridin-3-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl}-2-chlorobenzonitrile

: 1126771-31-0
methyl 5-{[4-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-1-yl]methyl}pyridine-2-carboxylate

Guidance literature:: With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; at 60 ℃; for 6h; Inert atmosphere;