(4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

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Chemical Name:(4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one
CAS No.:1432519-14-6
Molecular Formula:C₃₅H₃₉FO₄S₂
Molecular Weight:606.823
Hs Code.:

Synonyms:(4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

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Chemical Property of (4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

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Technology Process of (4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

There total 6 articles about (4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1432518-87-0
2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorobenzaldehyde

: 112968-75-9,122079-41-8,122079-45-2,135041-07-5,77934-87-3
(5R)-(L-menthyloxy)-2(5H)-furanone

: 1432519-14-6
(4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

Guidance literature:: With n-butyllithium; diphenyl diselenide; In tetrahydrofuran; hexane; at -60 - -20 ℃; for 8h;
DOI:10.1039/c3ob40115d

Reference yield:

: C₂₃H₂₃FO₂S₂

: 1432519-14-6
(4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

2: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

With hydrogenchloride; n-butyllithium; diphenyl diselenide; In tetrahydrofuran; hexane; water;
DOI:10.1039/c3ob40115d

Reference yield:

: 77532-79-7
3-fluoro-6-methylbenzonitrile

: 1432519-14-6
(4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane

2.1: diisobutylaluminium hydride; hydrogen bromide / dichloromethane / Cooling with ice

3.1: toluene-4-sulfonic acid / methanol / 1 h / 50 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 - 0 °C / Cooling with ice

4.2: 0.67 h / -78 - 0 °C / Cooling with ice

5.1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

6.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); diphenyl diselenide; hydrogen bromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water;
DOI:10.1039/c3ob40115d