(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

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Chemical Name:(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate
CAS No.:1432519-15-7
Molecular Formula:C₃₇H₄₁FO₅S₂
Molecular Weight:648.86
Hs Code.:

Synonyms:(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

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Chemical Property of (S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

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Technology Process of (S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

There total 7 articles about (S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1432519-14-6
(4R)-2-[(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}-(hydroxy)methyl]-4-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)-cyclohexyl]oxy}cyclopent-2-en-1-one

: 75-36-5
acetyl chloride

: 1432519-15-7
(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 3h; Cooling with ice;
DOI:10.1039/c3ob40115d

Reference yield:

: C₂₃H₂₃FO₂S₂

: 1432519-15-7
(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

2: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

3: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

With pyridine; hydrogenchloride; dmap; n-butyllithium; diphenyl diselenide; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1039/c3ob40115d

Reference yield:

: 77532-79-7
3-fluoro-6-methylbenzonitrile

: 1432519-15-7
(S)-{2-[2,2-bis(phenylsulfanyl)ethyl]-5-fluorophenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane

2.1: diisobutylaluminium hydride; hydrogen bromide / dichloromethane / Cooling with ice

3.1: toluene-4-sulfonic acid / methanol / 1 h / 50 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 - 0 °C / Cooling with ice

4.2: 0.67 h / -78 - 0 °C / Cooling with ice

5.1: hydrogenchloride / hexane; tetrahydrofuran; water / 3 h / Cooling with ice

6.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -60 - -20 °C

7.1: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

With pyridine; hydrogenchloride; dmap; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); diphenyl diselenide; hydrogen bromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; water;
DOI:10.1039/c3ob40115d