(S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

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Chemical Name:(S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
CAS No.:1584642-06-7
Molecular Formula:C₂₃H₂₀ClF₅N₆O
Molecular Weight:526.896
Hs Code.:

Synonyms:(S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

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Chemical Property of (S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

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Technology Process of (S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

There total 6 articles about (S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 249648-16-6
5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine

: 31121-11-6
3-hydroxy-N-phenylpropylamine

: 1584642-06-7
(S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: 3-hydroxy-N-phenylpropylamine; With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; at 60 ℃; for 1h;

5-chloro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; at 60 ℃;
DOI:10.1021/jm5005623

Reference yield: 53.0%

: 1584642-06-7
(S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; at 60 ℃; for 1h;

In tetrahydrofuran; dimethyl sulfoxide; at 60 ℃;

Reference yield:

: 262609-07-4
diethyl (2,4,6-trifluoro-phenyl)-malonate

: 1584642-06-7
(S)-5-chloro-6-(2,6-difluoro-4-(3-(phenylamino)propoxy)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tributyl-amine / 2 h / 170 °C

2.1: sodium hydroxide / toluene

3.1: trichlorophosphate / 6 h / 130 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C

5.1: sodium hydride / mineral oil; dimethyl sulfoxide; tetrahydrofuran / 1 h / 60 °C

5.2: 60 °C

With tributyl-amine; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm5005623