31121-11-6

Basic information

• Product Name: N-(3-Hydroxypropyl)aniline
• Synonyms: 3-Anilino-1-propanol;3-Phenylamino-1-propanol;N-(3-Hydroxypropyl)aniline;3-Anilino-1-propanol, N-(3-Hydroxypropyl)aniline
• CAS NO: 31121-11-6
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.21
• Mol File: 31121-11-6.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 140°C/0.4mmHg(lit.)
• Flash Point: 156.7°C
• Appearance: /
• Density: 1.084g/cm³
• Vapor Pressure: 0.000195mmHg at 25°C
• Refractive Index: 1.5710-1.5750
• Storage Temp.: 0-10°C
• PKA: 14.88±0.10(Predicted)
• CAS DataBase Reference: N-(3-Hydroxypropyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Hydroxypropyl)aniline(31121-11-6)
• EPA Substance Registry System: N-(3-Hydroxypropyl)aniline(31121-11-6)

Safety Data

• Hazardous Substances Data: 31121-11-6(Hazardous Substances Data)

Usage

General Description

N-(3-Hydroxypropyl)aniline is a chemical compound with the molecular formula C9H13NO. It is a derivative of aniline, which is a commonly used building block in the synthesis of dyes, pharmaceuticals, and other organic compounds. N-(3-Hydroxypropyl)aniline possesses a hydroxypropyl group attached to the nitrogen atom of the aniline ring. This structural feature gives the compound unique properties and potential applications in organic synthesis and material science. It is important to handle and use this chemical with caution due to its potential hazards, such as skin and eye irritation, and its toxic effects if ingested or inhaled.

InChI:InChI=1/C9H13NO/c11-8-4-7-10-9-5-2-1-3-6-9/h1-3,5-6,10-11H,4,7-8H2

Upstream product

• 6065-69-6 3-bromopropyl benzoate 
• 62-53-3 aniline 
• 627-30-5 1-chloro-3-hydroxypropane 
• 503-30-0 trimethylene oxide 
• 589-09-3 N-allyl-N-phenylamine 
• 591-50-4 iodobenzene 
• 156-87-6 propan-1-ol-3-amine 
• 504-63-2 trimethyleneglycol 
• 5099-95-6 1-phenylazetidin-2-one 
• 98-95-3 nitrobenzene 
• 109-78-4 3-Hydroxypropionitrile 
• 7617-76-7 3-phenoxypropanamine 
• 107-18-6 allyl alcohol 
• 103-84-4 Acetanilid 

Downstream Products

• 65869-15-0 3-((hydroxyethyl)(phenyl)amino)propan-1-ol 
• 19097-22-4 N-(3-hydroxy-propyl)-N,N-dimethyl-anilinium; iodide 
• 86651-96-9 2-Chloro-3-phenyl-1,3,2-oxazaphosphorinane 
• 50-00-0 formaldehyd 
• 74-85-1 ethene 
• 62-53-3 aniline 
• 121494-19-7 5-bromo-3-[N-(3-hydroxypropyl)-N-phenyl]carbamoylpyridine 
• 1106675-42-6 N-hexanoyl-3-(phenylamino)propanol 
• 230-27-3 7,8-benzoquinoline 
• 1093167-92-0 N-(naphthalen-1-yl)-N'-phenylpropane-1,3-diamine 
• 56535-86-5 3-phenyl-1,3-oxazinan-2-one 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 28819-40-1 tetrahydro-3-phenyl-1,3-oxazine 
• 22525-82-2 phenyl(3-phenyl-[1,3]-thiazinan-2-ylidene)amine 

Relevant articles and documents

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Visible light-mediated Smiles rearrangements and annulations of non-activated aromatics

We report the first examples of radical cation Smiles rearrangements. A series of aryloxy alkylamines underwent spontaneous reaction, with the amino group displacing theipso-alkoxy group through substitution, at ambient temperature and under photoactivation by visible light in the presence of an acridinium catalyst (5 mol%). The study was extended to 3-(2-methoxyphenyl)propan-1-amine derivatives, which lack an appropriateipsoleaving group. Here, efficient cyclisations resulted in displacement of the methoxy group and formation of tetrahydroquinolines.

Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.