4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

Base Information

Chemical Name:4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride
CAS No.:1454667-88-9
Molecular Formula:C₁₅H₁₄F₃N₃O*ClH
Molecular Weight:345.752
Hs Code.:

Synonyms:4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

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Chemical Property of 4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

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Technology Process of 4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

There total 1 articles about 4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053656-57-7
4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester

: 312936-89-3
(2-methoxy-4-(trifluoromethyl)phenyl)boronic acid

: 1454667-88-9
4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

Guidance literature:: 4-chloro-5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid tert-butyl ester; (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid; With potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 96-50-4
2-thiazolylamine

: 1454667-88-9
4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

: 1454666-80-8
4-(2-methoxy-4-(trifluoromethyl)phenyl)-N-(thiazol-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-sulfonamide

Guidance literature:: 2-thiazolylamine; With 1H-imidazole; sulfuryl dichloride; In dichloromethane; at -78 ℃;

4-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Reflux;