372199-85-4

Upstream product

• 824-79-3 sodium 4-methylbenzenesulfinate 
• 136401-24-6 benzyl N-(1-methoxy-1-phenylmethyl)carbamate 
• 5491-18-9 2-(benzyloxycarbonylamino)-2-phenylacetic acid 
• 621-84-1 O-benzyl carbamate 
• 100-52-7 benzaldehyde 

Downstream Products

• 948853-03-0 (S)-2-(benzyloxycarbonylaminophenylmethyl)malonic acid bis(4-methoxyphenyl) ester 
• 138723-71-4 benzyl (1-phenylbut-3-en-1-yl)carbamate 
• 321851-54-1 (1-phenyl-propyl)-carbamic acid benzyl ester 
• 1071052-16-8 benzyl (2-cyano-1-phenyl-allyl)carbamate 
• 911303-02-1 3-[(4-methylphenylsulfonyl)(phenyl)methyl]-1H-indole 
• 1190880-13-7 C₂₃H₂₄O₅S 
• 1190880-12-6 1,2,4-trimethoxy-5-(phenyl(p-toluenesulfonyl)methyl)benzene 
• 122724-99-6 (2,4-dimethoxy-phenyl)-phenyl-(toluene-4-sulfonyl)-methane 
• 911303-07-6 1-methyl-1-(2-methyl-1H-3-indolyl)ethyl (4-methylphenyl)sulfone 
• 1190880-01-3 C₂₃H₂₁NO₂S 
• 1190880-03-5 C₂₄H₂₁NO₄S 
• 930573-91-4 C₁₈H₁₉NO₃ 
• 127536-31-6 benzyl carbamate 
• 1243035-88-2 C₂₂H₂₄FNO₆ 

Relevant academic research and scientific papers

A novel approach for substitution of sulfonate group by (1H)-imidazole moiety: An application for synthesis of novel benzyl imidazolylcarbamates

An efficient and convenient substitution protocol was developed for the synthesis of novel benzyl (1-methyl-1H-imidazol-5-yl) (aryl) methyl carbamate derivatives from α-amido sulphones with a solution 5-bromo-1-methyl-(1H)-imidazole in THF under Hexamethy

An Efficient Copper-catalyzed Nucleophilic Addition to N-Acyliminium Ions Derived from N-Benzyloxycarbonylamino Sulfones: A Novel Approach to C-3 Functionalization of 2-Phenylimidazo[1,2-a]pyridine

A general and efficient method for C-3 functionalization of 2-phenylimidazo[1,2-a]pyridine has been developed. The reaction employs Cu(OTf)2 as a catalyst at 10 mol% loading, proceeds in dimethyl sulfoxide solvent, and utilizes bench-stable sol

1-(N -acylamino)alkyl sulfones from N -acyl-α-amino acids or N -alkylamides

A variety of N-(1-methoxyalkyl)amides or carbamates react readily with sodium aryl sulfinates in the presence of triphenylphosphonium tetrafluoroborate or bromide in CHCl3 under mild conditions to give 1-(N-acylamino)alkyl sulfones in good yiel

Leaving group and regioselectivity switches in the aminoalkylation reaction of indoles and related heterocycles with α-amido sulfones

The regioselective aminoalkylation of indoles and related heterocycles with α-amido sulfones under basic conditions has been studied. The reaction that employed the MeMgBr/MgBr2 system provided high yields of 3-(1-carbamoylalkyl)indoles. On the other hand, the reaction that used Cs 2CO3 afforded 1-(1-carbamoylalkyl)indoles exclusively in high yields. The first reaction constitutes a switch of the leaving group of the α-amido sulfone in comparison to previously reported reactions between indoles and α-amido sulfones, which provided 3-(1-arylsulfonylalkyl) indoles. The second reaction constitutes a switch in the regioselectivity. The extensions of these C- and N-aminoalkylations starting from pyrroles and 7-azaindole have also been studied. Structurally diverse aminoalkylated indoles, pyrroles, and 7-azaindoles were obtained with excellent yield in most of the cases. The regioselective aminoalkylation of indoles and heterocycles with α-amido sulfones under basic conditions is described. The reaction with MeMgBr/MgBr2 gives 3-(1-carbamoylalkyl)indoles, whereas employing Cs2CO3 yields 1-(1-carbamoylalkyl)indoles. The first case presents a switch of the leaving group of the α-amido sulfone, whereas the second demonstrates a switch in the regioselectivity. Copyright

A mild and efficient catalytic mannich-type reaction as a simple access to N -benzyloxycarbonyl -amino ketones

N-Benzyloxycarbonylamino sulfones react with aromatic ketones in the presence of catalytic amount of boron trifluoride-diethyl ether at room temperature to afford the corresponding protected β-amino ketones in high yields (71-87%). Georg Thieme Verlag Stu

Indium triflate-catalyzed allylation reactions of N-sulfonyl aldimines or N-alkoxycarbonylamino p-tolylsulfones with allyltrimethylsilane: Synthesis of protected homoallylic amines

Indium triflate-catalyzed allylation reactions of N-sulfonyl aldimines or N-alkoxyloxycarbonylamino p-tolylsulfone with allyltrimethylsilane have been successfully developed to produce protected homoallylic amines.

Asymmetric synthesis of maraviroc (UK-427,857)

The asymmetric synthesis of Maraviroc (UK-427,857), a chemochine receptor 5 (CCR-5) receptor antagonist, based on an expeditious organocatalytic enantioselective assembly of the chiral βamino aldehyde key fragment is presented. The reactions were performed on a gram-scale and allow for the rapid construction of new Maraviroc analogues.

InBr3: A versatile catalyst for the different types of Friedel-Crafts reactions

(Chemical Equation Presented) Mild and efficient InBr3-catalyzed Friedel-Crafts alkylation of heteroaromatic or electron-rich aromatic compounds with α-amido sulfones at room temperature in CH2Cl2 has been developed. The p