Prazepam

Base Information

• Chemical Name: Prazepam
• CAS No.: 2955-38-6
• Molecular Formula: C19H17 Cl N2 O
• Molecular Weight: 324.81
• Hs Code.: 2933910000
• European Community (EC) Number: 220-975-8
• NSC Number: 277179
• UNII: Q30VCC064M
• DSSTox Substance ID: DTXSID4021181
• Nikkaji Number: J3.397I
• Wikipedia: Prazepam
• Wikidata: Q2149443
• NCI Thesaurus Code: C66458
• Pharos Ligand ID: 7WK1AMSTSPVN
• Metabolomics Workbench ID: 43579
• ChEMBL ID: CHEMBL969
• Mol file: 2955-38-6.mol

Synonyms:Centrax;Demetrin;Lysanxia;Mono Demetrin;Prazepam;Reapam

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Prazepam

Chemical Property:

• Vapor Pressure: 1.15E-11mmHg at 25°C
• Melting Point: 145-146°
• Refractive Index: 1.5790 (estimate)
• Boiling Point: 538.5°Cat760mmHg
• PKA: pKa 2.94 (Uncertain)
• Flash Point: 279.5°C
• PSA: 32.67000
• Density: 1.31g/cm³
• LogP: 3.43460
• Storage Temp.: 2-8°C
• Solubility.: Dissolve 0.25 g in alcohol R and dilute to 10 mL with the same solvent. The solution is clear (2.2.1) and colourless (2.2.2, Method II).
• Water Solubility.: 9.095mg/L(25 oC)
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 324.1029409
• Heavy Atom Count: 23
• Complexity: 482

Purity/Quality:

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 22-24/25-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1CN2C(=O)CN=C(C3=C2C=CC(=C3)Cl)C4=CC=CC=C4
• Description: Prazepam (Item No. 18358) is an analytical reference material categorized as a benzodiazepine. Prazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications. Prazepam (CRM) (Item No. 21701) is a certified reference material categorized as a benzodiazepine. Prazepam is regulated as a Schedule IV compound in the United States. Prazepam (CRM) (Item No. 21701) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
• Uses: Sedative-hypnotic.
• Therapeutic Function: Tranquilizer

Technology Process of Prazepam

There total 3 articles about Prazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

carbon monoxide (201230-82-2) → 2-Chloro-5-cyclopropylmethyl-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-22-2) + 2-Chloro-5-cyclopropylmethyl-13b-methoxy-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-21-1) + 2-N-cyclopropmethylamino-5-chloro-benzophenone (2897-00-9) + prazepam (2955-38-6)

Guidance literature:

In methanol; chloroform; at 45 - 50 ℃; for 31h; under 76000.1 Torr;

DOI:10.1016/0022-328X(91)86234-H

Reference yield: 13.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) → 2-Chloro-5-cyclopropylmethyl-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-22-2) + 2-Chloro-5-cyclopropylmethyl-13b-methoxy-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-21-1) + 2-N-cyclopropmethylamino-5-chloro-benzophenone (2897-00-9) + prazepam (2955-38-6)

Guidance literature:

In chloroform; at 45 - 50 ℃; for 31h; under 76000.1 Torr; Title compound not separated from byproducts;

DOI:10.1016/0022-328X(91)86234-H

Reference yield:

→ prazepam (2955-38-6)

Guidance literature:

Aus /BRN= 751823/ mit Phenyllithium und /BRN= 605296/;

upstream raw materials:

carbon monoxide

methanol

Downstream raw materials:

(prazepam)AuCl

{(prazepam)Au(PPh₃)⁽¹⁺⁾BF₄^(1-)

(7-chloro-1-(cyclopropylmethyl)-1-3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one)AuCl₃

(C₁₉H₁₆ClN₂O)[Au(P(C₆H₅)3)]2⁽¹⁺⁾*BF₄^(1-)=[(C₁₉H₁₆ClN₂O)[Au(P(C₆H₅)3)]2]BF₄

Refernces

• 1、 -. "Process for the preparation of 1,4-benzodiazepine derivatives". . . Retrieved 2008/06/13.