1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate

Base Information

• Chemical Name: 1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate
• CAS No.: 955360-23-3
• Molecular Formula: C₂₄H₄₁NO₄Si
• Molecular Weight: 435.679
• Mol file: 955360-23-3.mol

Synonyms:1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate

Chemical Property of 1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate

There total 2 articles about 1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-(tert-butyldimethylsilyloxy)ethyl]phenol (96013-76-2) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate (955360-23-3)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) + tert-butyldimethylsilyl chloride (18162-48-6) → 1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate (955360-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 19 h / 21 °C

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 0 - 20 °C

With 1H-imidazole; di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

1,1-dimethylethyl 4-{[4-(2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)phenyl]oxy}-1-piperidinecarboxylate (955360-23-3) + trifluoroacetic acid (76-05-1) → 2-[4-(4-oiperidinyloxy)phenyl]ethyl trifluoroacetate trifluoroacetate (955360-25-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 17h;

upstream raw materials:

4-[2-(tert-butyldimethylsilyloxy)ethyl]phenol

t-butyl 4-hydroxy piperidine-1-carboxylate

p-hydroxyphenethyl alcohol

tert-butyldimethylsilyl chloride

Downstream raw materials:

2-[4-(4-oiperidinyloxy)phenyl]ethyl trifluoroacetate trifluoroacetate