6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

Chemical Name:6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
CAS No.:1257051-74-3
Molecular Formula:C₁₇H₂₀ClN₃O
Molecular Weight:317.818
Hs Code.:

Synonyms:6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Chemical Property of 6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Technology Process of 6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 3 articles about 6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1257051-74-3
6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / ethanol / 24 h / Reflux; Inert atmosphere

2: trichlorophosphate / 3 h / Reflux; Inert atmosphere

3: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With sodium methylate; sodium hydride; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1021/acs.jmedchem.6b00912

Reference yield:

: 778574-06-4
6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine

: 67-63-0,8013-70-5
isopropyl alcohol

: 1257051-74-3
6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: With sodium hydride; at 0 ℃; Inert atmosphere;

Reference yield:

: 135481-57-1
5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione

: 1257051-74-3
6-benzyl-2-chloro-4-isopropoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 3 h / Reflux; Inert atmosphere

2: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With sodium hydride; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/acs.jmedchem.6b00912