methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Base Information

Chemical Name:methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate
CAS No.:1268385-34-7
Molecular Formula:C₁₆H₁₆F₃NO₄
Molecular Weight:343.303
Hs Code.:

Synonyms:methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Chemical Property of methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Technology Process of methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

There total 5 articles about methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 67-56-1
methanol

: 1268385-33-6
{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

: 1268385-34-7
methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: With thionyl chloride; at 20 ℃;

Reference yield:

: 1234790-83-0
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde oxime

: 1268385-34-7
methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

1.2: Reflux

2.1: periodic acid / acetonitrile / 0 - 20 °C

2.2: 0 - 20 °C

3.1: thionyl chloride / 20 °C

With N-chloro-succinimide; thionyl chloride; periodic acid; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₁₁H₁₁ClF₃NO₂

: 1268385-34-7
methyl {3-[4-(Propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dichloro-ethane / 2 h / Inert atmosphere

2.1: pyridinium chlorochromate; periodic acid / acetonitrile / 3 h / 20 °C / Cooling with ice; Inert atmosphere

3.1: acetyl chloride / 0.08 h / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With periodic acid; triethylamine; acetyl chloride; pyridinium chlorochromate; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo4014595