6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Base Information

• Chemical Name: 6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• CAS No.: 443886-32-6
• Molecular Formula: C₂₀H₁₂BrF₃N₄O
• Molecular Weight: 461.241

Synonyms:6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Chemical Property of 6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

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Technology Process of 6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

There total 3 articles about 6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-bromo-benzaldehyde (1122-91-4) + phenylhydrazine (100-63-0) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) + malononitrile (109-77-3) → 6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (443886-32-6)

Guidance literature:

phenylhydrazine; ethyl 4,4,4-trifluoroacetoacetate; With zinc trifluoromethanesulfonate; In neat (no solvent); at 80 ℃; for 0.166667h; Microwave irradiation; Green chemistry;

4-bromo-benzaldehyde; malononitrile; In neat (no solvent); at 120 ℃; for 0.25h; Microwave irradiation; Green chemistry;

DOI:10.1016/j.molstruc.2021.131605

Reference yield: 86.0%

4-bromo-benzaldehyde (1122-91-4) + 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one (321-07-3) + malononitrile (109-77-3) → 6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (443886-32-6)

Guidance literature:

In water; at 90 ℃; for 3.5h;

DOI:10.1007/s11164-013-1058-7

Reference yield:

4-bromobenzylidenemalononitrile (2826-24-6) + 1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one (321-07-3) → 6-amino-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (443886-32-6)

Guidance literature:

In water; at 90 ℃; for 2h;

DOI:10.1007/s11164-013-1058-7

upstream raw materials:

4-bromobenzylidenemalononitrile

1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one

4-bromo-benzaldehyde

malononitrile

Downstream raw materials:

(S)-4-(4-bromophenyl)-1-phenyl-3-(trifluoromethyl)-1,4,6,7,8,9-hexahydropyrazolo[4',3':5,6]pyrano[2,3-b]quinolin-5-amine

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