5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Base Information

• Chemical Name: 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
• CAS No.: 1363693-47-3
• Molecular Formula: C₂₄H₃₄N₆O₄S
• Molecular Weight: 502.638
• Mol file: 1363693-47-3.mol

Synonyms:5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Chemical Property of 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

There total 4 articles about 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl sulfate (64-67-5) + 5-[2-hydroxy-5-(4-methylpiperazine-1-ylsulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one → 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine (1093065-15-6) + 5-[2-hydroxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine (1363693-50-8) + 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (1363693-47-3) + viagra (139755-83-2)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 20 ℃; for 4h; Inert atmosphere; Reflux;

DOI:10.2174/157017811799304304

Reference yield:

4-[2-hydroxy-5-(4-methylpiperazine-1-ylsulphonyl)benzamido]-1-methyl-3-n-propyl-1H-pyrazole-5-carboxamide (960009-36-3) → 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine (1093065-15-6) + 5-[2-hydroxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine (1363693-50-8) + 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (1363693-47-3) + viagra (139755-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / diethylene glycol

2: potassium carbonate; potassium iodide / acetone / 4 h / 20 °C / Inert atmosphere; Reflux

With potassium carbonate; potassium iodide; sodium hydroxide; In acetone; diethylene glycol;

DOI:10.2174/157017811799304304

Reference yield:

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (139756-02-8) → 5-[2-ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine (1093065-15-6) + 5-[2-hydroxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1-hydro-7-ethoxypyrazolo[4,3-d]pyrimidine (1363693-50-8) + 5-[2-ethoxy-5-(4-methylpiperazine-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-6-ethyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (1363693-47-3) + viagra (139755-83-2)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane

2: sodium hydroxide / diethylene glycol

3: potassium carbonate; potassium iodide / acetone / 4 h / 20 °C / Inert atmosphere; Reflux

With potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; potassium iodide; sodium hydroxide; In dichloromethane; acetone; diethylene glycol;

DOI:10.2174/157017811799304304

upstream raw materials:

diethyl sulfate

4-[2-hydroxy-5-(4-methylpiperazine-1-ylsulphonyl)benzamido]-1-methyl-3-n-propyl-1H-pyrazole-5-carboxamide

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)benzoic acid