o-Oxalotoluidide

Base Information

• Chemical Name: o-Oxalotoluidide
• CAS No.: 3299-62-5
• Molecular Formula: C16H16N2O2
• Molecular Weight: 268.315
• Hs Code.: 2924299090
• European Community (EC) Number: 665-999-3
• NSC Number: 11023
• DSSTox Substance ID: DTXSID60279013
• Wikidata: Q82011271
• ChEMBL ID: CHEMBL1504147
• Mol file: 3299-62-5.mol

Synonyms:o-Oxalotoluidide;3299-62-5;N1,N2-Di-o-tolyloxalamide;N,N'-bis(2-methylphenyl)oxamide;MLS000737936;CHEMBL1504147;N,N'-bis(2-methylphenyl)ethanediamide;o-Oxotoluidide;Ditolyloxamid;NSC11023;NSC 11023;N,N'-bis(o-tolyl)oxamide;SCHEMBL2344209;DTXSID60279013;N,N'-DI(O-TOLYL)OXAMIDE;HMS2886P15;BDBM50350694;NSC-11023;STK061965;AKOS000340095;SMR000528095;FT-0673323

Chemical Property of o-Oxalotoluidide

Chemical Property:

• Melting Point: 215 °C
• PKA: 11.11±0.70(Predicted)
• PSA: 58.20000
• Density: 1.241±0.06 g/cm3(Predicted)
• LogP: 3.02660
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 268.121177757
• Heavy Atom Count: 20
• Complexity: 322

Purity/Quality:

o-Oxalotoluidide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1NC(=O)C(=O)NC2=CC=CC=C2C

Technology Process of o-Oxalotoluidide

There total 18 articles about o-Oxalotoluidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

oxalyl dichloride (79-37-8) + o-toluidine (95-53-4) → N,N'-bis(o-tolyl)oxamide (3299-62-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 0 ℃;

DOI:10.1016/S0040-4020(01)00360-X

Reference yield: 65.0%

oxalic acid diethyl ester (95-92-1) + o-toluidine (95-53-4) → N,N'-bis(o-tolyl)oxamide (3299-62-5)

Guidance literature:

With sodium; In ethanol; for 1h; Heating;

DOI:10.3390/50500714

Reference yield: 32.0%

oxalic acid (144-62-7,97993-78-7) + o-toluidine (95-53-4) → N,N'-bis(o-tolyl)oxamide (3299-62-5)

Guidance literature:

With 4 A molecular sieve; In toluene; acetonitrile; at 150 ℃; 2 d; 2 d;

DOI:10.1016/0040-4020(95)00735-Q

upstream raw materials:

o-toluidine

N-(o-tolyl)-oxamic acid

oxalic acid

N,N'-bis(2-methylphenyl)ethane-bis(imidoyl) dichloride

Downstream raw materials:

2-Methyl-6-nitroaniline

N,N'-bis(2-methylphenyl)urea

N,N'-bis(2-methylphenyl)ethane-bis(imidoyl) dichloride

N,N'-bis-(2-methyl-4,6-dinitro-phenyl)-oxalamide