[2S-(2α(1S,2R),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Base Information

Chemical Name:[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran
CAS No.:866457-00-3
Molecular Formula:C₃₆H₄₃IO₃
Molecular Weight:650.64
Hs Code.:

Synonyms:[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

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Chemical Property of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

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Technology Process of [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

There total 2 articles about [2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 866456-95-3
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

: 866457-00-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In toluene; Heating;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866456-93-1
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

: 866457-00-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 93 percent / I₂; PPh₃; imidazole / toluene / Heating

With 1H-imidazole; lithium aluminium tetrahydride; iodine; triphenylphosphine; In diethyl ether; toluene;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield: 90.0%

: 866457-00-3
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-2-[2-(1-benzyl-2-iodo-1-methylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

: 866457-02-5
[2S-(2α(1S*,2R*),3aα,4β,7β,7aα)]-[2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenyl-ethoxy]octahydro-7,8,8-trimethyl-4,7-methanobenzofuran

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 67 ℃; for 16h;
DOI:10.1016/j.tetasy.2005.06.033