[2S-(2α(1R,2S),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester
CAS No.:866456-93-1
Molecular Formula:C₄₀H₅₀O₅
Molecular Weight:610.834
Hs Code.:

[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

Synonyms:[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

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Chemical Property of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

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Technology Process of [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

There total 1 articles about [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 866456-91-9
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester

: 109-72-8,29786-93-4
n-butyllithium

: 100-39-0
benzyl bromide

: (1R,2R,4R,6R,7R)-4-((S)-1,2-Diphenyl-ethoxy)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]decane

: 5-{1-[(1S,2R)-1,2-Diphenyl-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.0^2,6]dec-4-yloxy)-ethoxy]-ethyl}-nonan-5-ol

: 866456-93-1
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

Guidance literature:: [2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]propionic acid 1,1-dimethylethyl ester; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -15 ℃; for 1h;

n-butyllithium; In tetrahydrofuran; at -20 ℃; for 0.333333h;

benzyl bromide; In tetrahydrofuran; at -15 - 20 ℃;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield: 73.0%

: 866456-93-1
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

: 866456-95-3
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropane-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2005.06.033

Reference yield:

: 866456-93-1
[2S-(2α(1R*,2S*),3aα,4β,7β,7aα)]-2-[2-[(octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl)oxy]-1,2-diphenylethoxy]-2-benzylpropionic acid 1,1-dimethylethyl ester

: 866457-11-6
oxophenylacetic acid (1R,2S)-2-(1,1-dimethyl-2-phenylethoxy)-1,2-diphenylethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 93 percent / I₂; PPh₃; imidazole / toluene / Heating

3: 90 percent / LiBEt₃H / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / 67 °C

4: 0.125 g / p-TsOH / methanol; CH₂Cl₂ / 20 °C

5: 75 percent / diisopropylcarbodiimide; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; iodine; lithium triethylborohydride; toluene-4-sulfonic acid; triphenylphosphine; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2005.06.033