2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

Base Information

Chemical Name:2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol
CAS No.:152169-45-4
Molecular Formula:C₁₆H₂₁F₂NO₃
Molecular Weight:313.344
Hs Code.:

Synonyms:2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

Suppliers and Price of 2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

There total 7 articles about 2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 152169-44-3
2,4-difluoro-5-pivaloylaminophenol

: 152169-45-4
2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

Guidance literature:: With (1S)-10-camphorsulfonic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1055/s-1997-1379

Reference yield:

: 367-27-1
2,4-difluorophenol

: 152169-45-4
2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CH₂Cl₂ / 2 h / 10 - 20 °C

2: HNO₃, H₂SO₄ / 1 h / 10 - 20 °C

3: NaHCO₃, methanol / 16 h / Ambient temperature

4: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 27 h / 50 - 60 °C

5: 91 percent / pyridine / 0.5 h / 0 °C

6: 86 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; methanol; sulfuric acid; (1S)-10-camphorsulfonic acid; hydrogen; nitric acid; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1055/s-1997-1379

Reference yield:

: 152169-43-2
2,4-difluorophenyl ethyl carbonate

: 152169-45-4
2,4-difluoro-5-pivaloylamino-O-(2-tetrahydropyranyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: HNO₃, H₂SO₄ / 1 h / 10 - 20 °C

2: NaHCO₃, methanol / 16 h / Ambient temperature

3: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 27 h / 50 - 60 °C

4: 91 percent / pyridine / 0.5 h / 0 °C

5: 86 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; methanol; sulfuric acid; (1S)-10-camphorsulfonic acid; hydrogen; nitric acid; sodium hydrogencarbonate; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1055/s-1997-1379