<4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane

Base Information

• Chemical Name: <4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane
• CAS No.: 131446-97-4
• Molecular Formula: C₁₇H₂₆O₃
• Molecular Weight: 278.392
• Mol file: 131446-97-4.mol

Synonyms:<4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane

Chemical Property of <4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane

There total 7 articles about <4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

(2R)-1,2-O-isopropylidene-3-hydroxyheptan-1,2-diol (1093352-94-3) + benzyl chloride (100-44-7) → (2R, 3RS)-(+)-1,2,3-heptantriol-1,2-acetonide-3-benzyl ether (61981-44-0,87604-51-1,87604-52-2,131446-97-4)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 30 - 40 ℃; for 2h;

DOI:10.1016/S0040-4020(01)91303-1

Reference yield: 87.0%

n-propylmagnesium bromide (927-77-5) + (S)-2-(benzyloxy)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate (131446-96-3) → <4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane (131446-97-4)

Guidance literature:

With dilithium tetrachlorocuprate; In tetrahydrofuran; 1) -78 deg C, 1.5 h, 2) room temp., 65 h;

DOI:10.1016/S0040-4020(01)80881-4

Reference yield: 82.0%

(S)-4-((S,Z)-1-(benzyloxy)penta-2,4-dienyl)-2,2-dimethyl-1,3-dioxolane (1061228-16-7) → <4S,4(1S)>-4-<1-(Benzyloxy)pentyl>-2,2-dimethyl-1,3-dioxolane (131446-97-4)

Guidance literature:

With Crabtree's catalyst; hydrogen; In dichloromethane; at 25 ℃; for 12h; under 760.051 Torr;

DOI:10.1021/ol8018874

upstream raw materials:

n-propylmagnesium bromide

(S)-2-(benzyloxy)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate

<4S,4(1S)>-4-(1-Benzyloxy-2-iodoethyl)-2,2-dimethyl-1,3-dioxolane

2-O-benzyl-3,4-O-isopropylidene-L-threitol

Downstream raw materials:

Toluene-4-sulfonic acid (R)-3-benzyloxy-2-hydroxy-heptyl ester

(2R, 3RS)-(-)-1,2-epoxy-3-benzyloxyheptane

(2R, 3RS)-(+)-1,2,3-heptanetriol-3-benzylether

methyl <3S,5R,5(1S)>-N-benzyl-5-<1-(benzyloxy)pentyl>isoxazolidine-3-carboxylate