methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester
CAS No.:336883-78-4
Molecular Formula:C₂₂H₂₇NO₅S
Molecular Weight:417.526
Hs Code.:

Synonyms:methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester

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Chemical Property of methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester

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Technology Process of methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester

There total 1 articles about methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 336883-76-2
6,7,10,11-tetrahydro-9-[(phenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione

: 7143-01-3
Methanesulfonic anhydride

: 336883-78-4
methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 0.25h;
DOI:10.1021/jo001605g

Reference yield: 90.0%

: 79-37-8
oxalyl dichloride

: 124-41-4
sodium methylate

: 336883-78-4
methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester

: 336883-79-5
methyl 2-(1-{3-[2-(methylsulfonyloxy)ethoxy]-4-(phenylmethoxy)butyl}indol-3-yl)-2-oxoacetate

Guidance literature:: oxalyl dichloride; methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester; In diethyl ether; at 0 ℃; for 0.5h;

sodium methylate; In methanol; diethyl ether; at -60 - 20 ℃; Further stages.;
DOI:10.1021/jo001605g

Reference yield:

: 336883-78-4
methanesulfonic acid 2-(1-benzyloxymethyl-3-indol-1-yl-propoxy)-ethyl ester

: 336883-76-2
6,7,10,11-tetrahydro-9-[(phenylmethoxy)methyl]-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether / 0.5 h / 0 °C

1.2: 90 percent / methanol; diethyl ether / -60 - 20 °C

2.1: NaH / dimethylformamide / 0.75 h / 20 °C

2.2: 58 percent / dimethylformamide / 1.5 h / 0 - 20 °C

With sodium hydride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo001605g