Benzene, 1,1'-sulfonylbis[4-fluoro-

Base Information

• Chemical Name: Benzene, 1,1'-sulfonylbis[4-fluoro-
• CAS No.: 383-29-9
• Deprecated CAS: 2356275-28-8
• Molecular Formula: C12H8F2O2S
• Molecular Weight: 254.257
• Hs Code.: 29309070
• European Community (EC) Number: 206-847-4
• NSC Number: 683542,87584
• UNII: KW93VS9RT8
• DSSTox Substance ID: DTXSID2059934
• Nikkaji Number: J124.093E
• Wikidata: Q72476464
• Mol file: 383-29-9.mol

Synonyms:383-29-9;4-Fluorophenyl sulfone;4,4'-Sulfonylbis(fluorobenzene);4,4'-Difluorodiphenyl sulfone;Benzene, 1,1'-sulfonylbis[4-fluoro-;Bis(4-fluorophenyl)sulfone;Bis(p-fluorophenyl) sulfone;Bis(4-fluorophenyl) sulfone;4-fluorophenyl sulphone;4-Fluorophenylsulfone;Sulfone, bis(p-fluorophenyl);4,4'-Difluorodiphenyl sulphone;1,1'-sulfonylbis(4-fluorobenzene);Bis(p-fluorophenyl)sulphone;C12H8F2O2S;1-fluoro-4-(4-fluorophenyl)sulfonylbenzene;bis(p-fluorophenyl)sulfone;MFCD00000350;NSC 87584;Benzene, 1,1'-sulfonylbis(4-fluoro-;NSC 683542;KW93VS9RT8;4,4'-Difluorodiphenylsulfone;NSC87584;EINECS 206-847-4;NSC-87584;NSC683542;NSC-683542;1,1'-Sulfonylbis[4-fluorobenzene];bis(4-fluorophenyl)sulphone;Enamine_005215;1-fluoro-4-(4-fluorobenzenesulfonyl)benzene;1-fluoro-4-(4-fluorophenyl)sulfonyl-benzene;p,p'-Difluordiphenylsulfon;UNII-KW93VS9RT8;Cambridge id 5192838;Oprea1_616663;SCHEMBL79787;bis(4-fluorophenyl) sulphone;Bis-(4-fluorophenyl) sulfone;Sulphone, bis(p-fluorophenyl);Bis-(4-fluorophenyl) sulphone;Sulfone, bis(4-fluorophenyl)-;DTXSID2059934;Benzene,1'-sulfonylbis[4-fluoro-;HMS1408N01;Bis(4-fluorophenyl) sulfone, 99%;C12-H8-F2-O2-S;1,1'-Sulphonylbis[4-fluorobenzene];BBL023351;STL355979;AKOS001064866;AC-4575;CS-W010189;DS-1286;PS-7428;Benzene, 1,1'-sulphonylbis(4-fluoro-;IDI1_007802;NCGC00329318-01;SY038237;AM20060916;D0537;FT-0623038;O11120;1-Fluoro-4-[(4-fluorophenyl)sulfonyl]benzene #;AB01222579-03;A824113;W-106491;Z56888626;4,4 inverted exclamation mark -Difluorodiphenyl Sulfone

Chemical Property of Benzene, 1,1'-sulfonylbis[4-fluoro-

Chemical Property:

• Appearance/Colour: White crystal
• Vapor Pressure: 0.00983mmHg at 25°C
• Melting Point: 98-100 °C(lit.)
• Refractive Index: 1.496
• Boiling Point: 367.9 °C at 760 mmHg
• Flash Point: 176.3 °C
• PSA: 42.52000
• Density: 1.365 g/cm³
• LogP: 3.87840
• Storage Temp.: Store below +30°C.
• Solubility.: soluble in Methanol
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 254.02130699
• Heavy Atom Count: 17
• Complexity: 306

Purity/Quality:

97% ^*data from raw suppliers

4-Fluorophenylsulfone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Halogenated Polyaromatics
• Canonical SMILES: C1=CC(=CC=C1F)S(=O)(=O)C2=CC=C(C=C2)F
• Uses: 4-Fluorophenylsulfone was used in substitution reactions with deprotonated amines.

Technology Process of Benzene, 1,1'-sulfonylbis[4-fluoro-

There total 18 articles about Benzene, 1,1'-sulfonylbis[4-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bis(4-fluorophenyl)sulfoxide (395-25-5) → bis(p-fluorophenyl)sulfone (383-29-9)

Guidance literature:

With C₇H₄Cl₂N₂O₃; In tetrachloromethane; Heating;

Reference yield: 90.0%

fluorobenzene (462-06-6) → bis(p-fluorophenyl)sulfone (383-29-9)

Guidance literature:

With dipotassium peroxodisulfate; trifluorormethanesulfonic acid; tetra(n-butyl)ammonium hydrogensulfate; trifluoroacetic anhydride; In 1,2-dichloro-ethane; at 80 ℃; for 11h; Sealed tube;

DOI:10.1039/c4cc05964f

Reference yield: 88.0%

sodium 4-fluorobenzenesulfinate (824-80-6) → bis(p-fluorophenyl)sulfone (383-29-9)

Guidance literature:

With copper diacetate; In acetonitrile; at 60 ℃; for 3h;

DOI:10.3184/174751914X13946336636551

upstream raw materials:

fluorobenzene

4-Fluorobenzenesulfonyl chloride

4,4'-difluorodiphenyl sulfide

bis(4-fluorophenyl)sulfoxide

Downstream raw materials:

3,3′,5,5′-tetraphenyl-4,4′-difluorodiphenyl sulfone

3,3'-dibromo-4,4'-difluorodiphenyl sulfone

3,3'-diphenyl-4,4'-difluorodiphenyl sulfone

potassium 4-fluoro-4'-hydroxydiphenyl sulfonate