Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester
CAS No.:156350-21-9
Molecular Formula:C₂₂H₃₃NO₄SSi
Molecular Weight:435.66
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester

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Chemical Property of Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester

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Technology Process of Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester

There total 6 articles about Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146499-47-0
(2R,3R)-3-azido-2-tert-butyldimethylsiloxy-3-phenyl-1-p-toluenesulfonyloxypropane

: 156350-21-9
Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(00)74779-4

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 156350-21-9
Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 19 h / Ambient temperature

2: 1.33 g / 5percent Pd-C, HCO₂NH₄ / methanol / 1 h / Ambient temperature

With 1H-imidazole; palladium on activated charcoal; ammonium formate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80749-3

Reference yield:

: 121745-57-1
(2R,3R)-3-azido-3-phenyl-propane-1,2diol

: 156350-21-9
Toluene-4-sulfonic acid (2R,3R)-3-amino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 398 mg / Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

2: imidazole / dimethylformamide / 19 h / Ambient temperature

3: 1.33 g / 5percent Pd-C, HCO₂NH₄ / methanol / 1 h / Ambient temperature

With 1H-imidazole; palladium on activated charcoal; ammonium formate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80749-3