Chemical Property of 3-(Diaminomethylidene)-1,1-dimethylguanidine;hydron;chloride
Chemical Property:
- Appearance/Colour:crystalline solid
- Vapor Pressure:0.0929mmHg at 25°C
- Melting Point:223-226 °C(lit.)
- Boiling Point:224.1 °C at 760 mmHg
- PKA:12.4[at 20 ℃]
- Flash Point:89.3 °C
- PSA：88.99000
- Density:1.36[at 20℃]
- LogP:1.05850
- Storage Temp.:Store at RT
- Solubility.:Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride
- Water Solubility.:Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:165.0781231
- Heavy Atom Count:10
- Complexity:132
- Purity/Quality:
-
99% *data from raw suppliers
Metformin Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn,T,F
- Statements:
22-36/38-39/23/24/25-23/24/25-11
- Safety Statements:
26-36-45-36/37-16-7
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:[H+].CN(C)C(=N)N=C(N)N.[Cl-]
-
Production method
After the salifying of dimethylamine and the reaction with dicyandiamide , the product is derived.
-
Description
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.
-
Uses
An oral hypoglycemic agent Anti-diabetic and anti-cancer activity Metformin hydrochloride may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations and human plasma samples by analytical techniques. 1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
-
Therapeutic Function
Oral hypoglycemic
-
Clinical Use
Non-insulin dependent diabetes mellitus
Polycystic ovary syndrome
-
Drug interactions
Potentially hazardous interactions with other drugs
Alcohol: increased risk of lactic acidosis.
Cimetidine: inhibits renal excretion of metformin
