3-(Diaminomethylidene)-1,1-dimethylguanidine;hydron;chloride

Base Information Edit

Chemical Name:3-(Diaminomethylidene)-1,1-dimethylguanidine;hydron;chloride
CAS No.:1115-70-4
Molecular Formula:C4H12ClN5
Molecular Weight:165.626
Hs Code.:29252900
Mol file:1115-70-4.mol

Synonyms:AKOS026749936

Suppliers and Price of 3-(Diaminomethylidene)-1,1-dimethylguanidine;hydron;chloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Metformin Hydrochloride
1g
$ 55.00

Tocris
Metformin Hydrochloride
100
$ 83.00

TCI Chemical
Metformin Hydrochloride >98.0%(HPLC)(T)
25g
$ 78.00

TCI Chemical
Metformin Hydrochloride >98.0%(HPLC)(T)
100g
$ 228.00

SynQuest Laboratories
1,1-Dimethylbiguanide hydrochloride
500 g
$ 224.00

SynQuest Laboratories
1,1-Dimethylbiguanide hydrochloride
100 g
$ 112.00

Sigma-Aldrich
Metformin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
500mg
$ 79.50

Sigma-Aldrich
1,1-Dimethylbiguanide hydrochloride 97%
5g
$ 78.30

Sigma-Aldrich
Metformin hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
1 mL
$ 103.00

Sigma-Aldrich
Metformin hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
072-1ml
$ 99.60

Total 192 raw suppliers

Chemical Property of 3-(Diaminomethylidene)-1,1-dimethylguanidine;hydron;chloride Edit

Chemical Property:

Appearance/Colour:crystalline solid
Vapor Pressure:0.0929mmHg at 25°C
Melting Point:223-226 °C(lit.)
Boiling Point:224.1 °C at 760 mmHg
PKA:12.4[at 20 ℃]
Flash Point:89.3 °C
PSA：88.99000
Density:1.36[at 20℃]
LogP:1.05850
Storage Temp.:Store at RT
Solubility.:Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride
Water Solubility.:Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:165.0781231
Heavy Atom Count:10
Complexity:132

Purity/Quality:

99%, ^*data from raw suppliers

Metformin Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn,T,F
Statements: 22-36/38-39/23/24/25-23/24/25-11
Safety Statements: 26-36-45-36/37-16-7

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:[H+].CN(C)C(=N)N=C(N)N.[Cl-]
Production method After the salifying of dimethylamine and the reaction with dicyandiamide , the product is derived.
Description Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.
Uses An oral hypoglycemic agent Anti-diabetic and anti-cancer activity Metformin hydrochloride may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations and human plasma samples by analytical techniques. 1,1-Dimethylbiguanide hydrochloride is used as an antidiabetic agent, used in polycystic ovary syndrome, non-alcoholic fatty liver disease and diabetes mellitus type 2. It may also reduce weight gain in people taking atypical antipsychotics, used in a study to investigate its role in enhancing the secretions of plasma active glucagon-like peptide-1 (GLP-1) levels.
Therapeutic Function Oral hypoglycemic
Clinical Use Non-insulin dependent diabetes mellitus Polycystic ovary syndrome
Drug interactions Potentially hazardous interactions with other drugs Alcohol: increased risk of lactic acidosis. Cimetidine: inhibits renal excretion of metformin

Technology Process of 3-(Diaminomethylidene)-1,1-dimethylguanidine;hydron;chloride

There total 5 articles about 3-(Diaminomethylidene)-1,1-dimethylguanidine;hydron;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%