methyl 2-phenylethyl propanedioate

Base Information

• Chemical Name: methyl 2-phenylethyl propanedioate
• CAS No.: 153874-58-9
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 153874-58-9.mol

Synonyms:methyl 2-phenylethyl propanedioate

Chemical Property of methyl 2-phenylethyl propanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-phenylethyl propanedioate

There total 1 articles about methyl 2-phenylethyl propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-phenylethanol (60-12-8) + malonic acid dimethyl ester (108-59-8) → methyl 2-phenylethyl propanedioate (153874-58-9)

Guidance literature:

at 50 ℃; for 18h; subtilisin;

DOI:10.1002/hlca.19930760823

Reference yield:

methyl 2-phenylethyl propanedioate (153874-58-9) → 2-phenylethyl (E)-cinnamate (103-53-7,107584-56-5,63238-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine, molecular sieves / pyridine / 2 h / 80 °C

2: LiBr, AcONa / dimethylformamide / 6 h / 130 °C

3: dimethylformamide / 8 h / 160 °C

With piperidine; molecular sieve; sodium acetate; lithium bromide; In pyridine; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19930760823

Reference yield:

benzaldehyde (100-52-7) + methyl 2-phenylethyl propanedioate (153874-58-9) → methyl 2-phenylethyl 2-(phenylmethylidene)propanedioate (153874-59-0)

Guidance literature:

With piperidine; molecular sieve; In pyridine; at 80 ℃; for 2h;

DOI:10.1002/hlca.19930760823

upstream raw materials:

2-phenylethanol

malonic acid dimethyl ester

Downstream raw materials:

methyl 2-phenylethyl 2-(phenylmethylidene)propanedioate

2-phenylethyl (E)-cinnamate

2-phenylethyl hydrogen 2-(phenylmethylidene)propanedioate

Refernces