(3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one

Base Information

• Chemical Name: (3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one
• CAS No.: 1365552-53-9
• Molecular Formula: C₂₁H₁₇NO₃S
• Molecular Weight: 363.437
• Mol file: 1365552-53-9.mol

Synonyms:(3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one

Chemical Property of (3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one

There total 10 articles about (3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-tosyldiphenylmethylamine (853-83-8) + carbon monoxide (201230-82-2) → (3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one (1365552-53-9)

Guidance literature:

With t-Boc-L-valine; oxygen; palladium diacetate; caesium carbonate; copper dichloride; In isopropyl alcohol; at 80 ℃; for 24h; Temperature; Reagent/catalyst;

Reference yield: 67.0%

(R)-N-((o-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide + perfluorobenzaldehyde (653-37-2) → (3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one (1365552-53-9)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,3-bis-(diphenylphosphino)propane; potassium carbonate; potassium iodide; In 5,5-dimethyl-1,3-cyclohexadiene; at 130 ℃; for 24h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/jo300201g

Reference yield: 52.0%

N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) + (S)-(2-(methoxymethyl)pyrrolidin-1-yl)(phenyl)methanone → (3S)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one + (3R)-2,3-dihydro-2-[(4-methylphenyl)sulfonyl]-3-phenyl-1H-isoindol-1-one (1365552-53-9)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper diacetate; aluminum isopropoxide; In dichloromethane; at 100 ℃; for 48h; Reagent/catalyst; Solvent; enantioselective reaction; Catalytic behavior; Inert atmosphere; Molecular sieve;

DOI:10.1002/chem.202103319

upstream raw materials:

perfluorobenzaldehyde

N-tosyldiphenylmethylamine

carbon monoxide

formaldehyd