Chemical Property of Chlorothiazide
Chemical Property:
- Appearance/Colour:white crystalline powder
- Melting Point:342-343 ºC
- Refractive Index:1.801
- Boiling Point:608.8°Cat760mmHg
- PKA:6.85, 9.45(at 25℃)
- Flash Point:322°C
- PSA：135.45000
- Density:2.04g/cm3
- LogP:2.56540
- Storage Temp.:2-8°C
- Solubility.:DMSO (Slightly), Methanol (Very Slightly, Heated)
- Water Solubility.:<0.1 g/100 mL at 19.5℃
- XLogP3:-0.2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:1
- Exact Mass:294.9488257
- Heavy Atom Count:17
- Complexity:532
- Purity/Quality:
-
99%, *data from raw suppliers
Chlorothiazide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:Xn
- Statements:
42/43-20/21/22
- Safety Statements:
36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
- Recent ClinicalTrials:Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Severe Primary Hypoparathyroidism
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Description
Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.
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Uses
This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for
arterial hypertension, in edematous syndromes of various genesis, congestive effects in
cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended
for hypertonic illnesses. It lowers intraocular pressure in a number of cases. Diuretic; antihypertensive. Hydrochlorothiazide EP Impurity A.
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Therapeutic Function
Diuretic; Antihypertensive
