N-Acetyl-L-isoleucine ethyl ester

Base Information

• Chemical Name: N-Acetyl-L-isoleucine ethyl ester
• CAS No.: 4819-22-1
• Molecular Formula: C10H19 N O3
• Molecular Weight: 201.26
• Mol file: 4819-22-1.mol

Synonyms:Isoleucine,N-acetyl-, ethyl ester, L- (8CI); N-Acetyl-L-isoleucine ethyl ester

Chemical Property of N-Acetyl-L-isoleucine ethyl ester

Chemical Property:

• PSA: 58.89000
• LogP: 1.94060
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(2S,3S)-Ethyl2-acetamido-3-methylpentanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Acetyl-L-isoleucine ethyl ester

There total 6 articles about N-Acetyl-L-isoleucine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl N-acetyl-isoleucinate (2256-90-8,4662-54-8,4819-22-1,5846-06-0,74985-79-8) → N-acetyl-L-isoleucine (3077-46-1,5854-47-7,19764-31-9,20257-17-4,33601-90-0,54831-20-8,73465-39-1) + N-acetyl-d-isoleucine (3077-46-1,5854-47-7,19764-31-9,20257-17-4,33601-90-0,54831-20-8,73465-39-1) + (R)-2-Acetylamino-3-methyl-pentanoic acid ethyl ester (2256-90-8,4662-54-8,4819-22-1,5846-06-0,74985-79-8)

Guidance literature:

at 35 ℃; for 48h; Yield given. Yields of byproduct given; in the present of Saccharomyces cerevisiae Hansen;

DOI:10.1016/S0040-4039(00)94256-4

Reference yield:

ethanol (64-17-5) + (2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid (5854-47-7,19764-31-9,20257-17-4,33601-90-0,54831-20-8,73465-39-1,3077-46-1) → N-Acetyl-DL-isoleucin-ethylester (4819-22-1)

Guidance literature:

With benzene; unter Zusatz von wenig konz.H₂SO₄;

DOI:10.1021/ja01118a018

Reference yield:

L-isoleucine ethyl ester (921-74-4) + acetyl chloride (75-36-5) → N-Acetyl-DL-isoleucin-ethylester (4819-22-1)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S1386-1425(02)00031-8

upstream raw materials:

ethanol

(2S,3S)-N-acetyl-2-amino-3-methylpentanoic acid

L-isoleucine ethyl ester

acetyl chloride

Downstream raw materials:

N-acetyl-L-isoleucine

N-acetyl-d-isoleucine

(R)-2-Acetylamino-3-methyl-pentanoic acid ethyl ester

Refernces

• 1、 -. "ANTI-ODOR COMPOSITIONS AND THERAPEUTIC USE". . . Retrieved 2008/06/13.
• 2、 Glaenzer, B.I.,Faber, K.,Griengl, H.. "ENANTIOSELECTIVE HYDROLYSIS BY BAKER'S YEAST". . p. 4293 - 4294. Retrieved 2007/10/02.