3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester

Base Information

Chemical Name:3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester
CAS No.:952527-38-7
Molecular Formula:C₂₅H₂₅NO₄S
Molecular Weight:435.544
Hs Code.:

Synonyms:3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester

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Chemical Property of 3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester

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Technology Process of 3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester

There total 6 articles about 3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 67-56-1
methanol

: 952527-77-4
carbonic acid methyl ester 1-[1-(toluene-4-sulfonyl)-1H-indol-3-ylethynyl]-cyclohexyl ester

: 201230-82-2
carbon monoxide

: 952527-38-7
3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In benzene; at 25 ℃; for 24h;
DOI:10.1021/ol7018086

Reference yield:

: 120-72-9
indole

: 952527-38-7
3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: I₂; KOH / dimethylformamide / 2 h / 25 °C

2.1: 86 percent / NaOH / benzene / 2 h / 25 °C

3.1: 18.4 g / Et₃N; PPh₃; CuI / Pd(OAc)2 / 16 h / 80 °C

4.1: 12.12 g / TBAF / tetrahydrofuran / 0.08 h / 20 °C

5.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

5.2: tetrahydrofuran; hexane / 2 h / -78 °C

5.3: 64 percent / tetrahydrofuran; hexane / 2 h / 0 °C

6.1: 80 percent / Pd(PPh₃)4 / benzene / 24 h / 25 °C

With potassium hydroxide; sodium hydroxide; copper(l) iodide; n-butyllithium; tetrabutyl ammonium fluoride; iodine; triethylamine; triphenylphosphine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ol7018086

Reference yield:

: 952527-75-2
1-tosyl-3-((trimethylsilyl)ethynyl)-1H-indole

: 952527-38-7
3-cyclohexylidene-2-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 12.12 g / TBAF / tetrahydrofuran / 0.08 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / 2 h / -78 °C

2.3: 64 percent / tetrahydrofuran; hexane / 2 h / 0 °C

3.1: 80 percent / Pd(PPh₃)4 / benzene / 24 h / 25 °C

With n-butyllithium; tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; benzene;
DOI:10.1021/ol7018086