1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Base Information

Chemical Name:1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide
CAS No.:1176761-04-8
Molecular Formula:C₂₀H₂₄F₃N₅O
Molecular Weight:407.439
Hs Code.:

Synonyms:1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

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Chemical Property of 1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

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Technology Process of 1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

There total 5 articles about 1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1176761-16-2
1-[6-chloro-2-methyl-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

: 74-89-5
methylamine

: 1176761-04-8
1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: In ethanol; at 70 ℃; for 72h;

Reference yield:

: 3048-01-9
o-trifluoromethylbenzylamine

: 1176761-04-8
1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 10 °C

2: trifluoroacetic acid / 1 h / 0 °C

3: sodium hydroxide / 1,4-dioxane; water / 1 h / 180 °C / Microwave irradiation

4: ethanol / 72 h / 70 °C / Sealed tube

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; water;
DOI:10.1016/j.bmcl.2013.04.019

Reference yield:

: 1141894-92-9
4-[[[[2-(trifluoromethyl)phenyl]methyl]amine]carbonyl]-1-piperidinecarboxylic acid 1,1-dimethyl-ethyl ester

: 1176761-04-8
1-[2-methyl-6-(methylamino)-4-pyrimidinyl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1 h / 0 °C

2: sodium hydroxide / 1,4-dioxane; water / 1 h / 180 °C / Microwave irradiation

3: ethanol / 72 h / 70 °C / Sealed tube

With trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmcl.2013.04.019