ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate
CAS No.:1447711-37-6
Molecular Formula:C₂₁H₂₉NO₃
Molecular Weight:343.466
Hs Code.:

Synonyms:ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

There total 8 articles about ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1447711-35-4
ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

: 1447711-37-6
ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

Guidance literature:: With palladium on activated charcoal; ammonium formate; In methanol; ethyl acetate; at 25 ℃; for 1h;
DOI:10.1016/j.bmcl.2017.01.084

Reference yield:

: 1447711-33-2
ethyl 5-(3-(4-(benzyloxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxylate

: 1447711-37-6
ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 2 h / 25 °C

2.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

With palladium on activated charcoal; ammonium formate; sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

: 42113-13-3
methyl 4-hydroxy-3-methylbenzoate

: 1447711-37-6
ethyl 5-(3-(4-hydroxy-3-methylphenyl)-pentan-3-yl)-1-ethyl-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium iodide / 6 h / Reflux

2.1: diethyl ether / 2 h / 0 - 30 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 2 h / 25 °C

5.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

With palladium on activated charcoal; boron trifluoride diethyl etherate; ammonium formate; sodium hydride; potassium carbonate; potassium iodide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.09.015