7-BENZOYL-1,3-DIHYDRO-INDOL-2-ONE

Base Information

• Chemical Name: 7-BENZOYL-1,3-DIHYDRO-INDOL-2-ONE
• CAS No.: 51135-38-7
• Molecular Formula: C15H11NO2
• Molecular Weight: 237.258
• Hs Code.: 2933790090
• Mol file: 51135-38-7.mol

Synonyms:7-Benzoyl-2-indolinone;7-Benzoyloxindole;7-Benzoylindolin-2-one;

Chemical Property of 7-BENZOYL-1,3-DIHYDRO-INDOL-2-ONE

Chemical Property:

• Vapor Pressure: 3.39E-10mmHg at 25°C
• Melting Point: 154℃
• Refractive Index: 1.627
• Boiling Point: 501.7 °C at 760 mmHg
• PKA: 13.42±0.20(Predicted)
• Flash Point: 214.3 °C
• PSA: 46.17000
• Density: 1.254 g/cm³
• LogP: 2.55020
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

99% ^*data from raw suppliers

7-Benzoyloxindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Benzoyloxindole is an indole derivative with antiinflammatory activity. It is also a metabolite of amfenac (A576500).

Technology Process of 7-BENZOYL-1,3-DIHYDRO-INDOL-2-ONE

There total 14 articles about 7-BENZOYL-1,3-DIHYDRO-INDOL-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-benzoyl-3-methylsulfanyl-1,3-dihydro-indol-2-one (61085-33-4) → 7-benzoyl-1,3-dihydroindol-2-one (51135-38-7)

Guidance literature:

With nickel; In tetrahydrofuran; for 0.166667h;

DOI:10.1021/jm00377a001

Reference yield: 92.1%

nepafenac (78281-72-8) → 7-benzoyl-1,3-dihydroindol-2-one (51135-38-7)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 30 ℃; for 3h; Temperature; Reagent/catalyst; Solvent;

Reference yield: 89.0%

2-oxoindoline-7-carbonitrile (380427-40-7) + phenylboronic acid (98-80-6) → 7-benzoyl-1,3-dihydroindol-2-one (51135-38-7)

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water; In 2-methyltetrahydrofuran; at 80 ℃; for 36h; Schlenk technique;

DOI:10.1039/c4ob00978a

upstream raw materials:

formaldehyd

2-amino-3-benzoylbenzeneacetic acid,ethyl ester

7-benzoyl-3-methylsulfanyl-1,3-dihydro-indol-2-one

3-chloro-7-benzoylindole

Downstream raw materials:

2-amino-3-benzoylbenzeneacetic acid,sodium salt

amfenac

Ethyl 7-benzoyloxindole-3-carboxylate

Refernces

• 1、 -. "Preparation method of 7-benzoyl-1,3-indoline-2-ketone". Paragraph 0031; 0032. . Retrieved 2016/11/14.
• 2、 Walsh,Moran,Shamblee,Uwaydah,Welstead Jr.,Sancilio,Dannenburg. "Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues". . p. 1379 - 1388. Retrieved 2007/10/02.