methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate

Base Information

Chemical Name:methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate
CAS No.:540524-74-1
Molecular Formula:C₃₄H₃₂ClNO₄
Molecular Weight:554.085
Hs Code.:

Synonyms:methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate

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Chemical Property of methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate

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Technology Process of methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate

There total 7 articles about methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 540524-73-0
3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

: 540524-74-1
methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: 3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid; With oxalyl dichloride; In dichloromethane; for 1h;

With zinc(II) tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; for 0.25h; Further stages.;
DOI:10.1021/jm061131z

Reference yield: 83.0%

: 540524-73-0
3-(5-chloro-1-(diphenylmethyl)-3-{2-[4-(methoxycarbonyl)phenoxy]ethyl}-1H-indol-2-yl)propanoic acid

: 79-37-8
oxalyl dichloride

: 540524-74-1
methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: With zinc borohydride; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; dichloromethane; water;

Reference yield:

: 479422-24-7
methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

: 540524-74-1
methyl 4-{2-[5-chloro-1-(diphenylmethyl)-2-(3-hydroxypropyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2.1: 0.750 g / Ag₂CO₃; H₂O / acetone

3.1: 91 percent / tetrahydrofuran / 1 h

4.1: 97 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 4 h

5.1: 79 percent / H₂ / Pt/C / methanol / 24 h / 760.05 Torr

6.1: (COCl)2 / CH₂Cl₂ / 1 h

6.2: 83 percent / Zn(BH₄)2; TMEDA / diethyl ether / 0.25 h

With morpholine; N-Bromosuccinimide; oxalyl dichloride; water; hydrogen; silver carbonate; dibenzoyl peroxide; platinum on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; acetone;
DOI:10.1021/jm061131z