4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

Base Information

Chemical Name:4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester
CAS No.:1073549-05-9
Molecular Formula:C₂₆H₃₂FN₃O₃
Molecular Weight:453.557
Hs Code.:

Synonyms:4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

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Chemical Property of 4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

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Technology Process of 4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

There total 11 articles about 4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1073549-08-2
4'-[2-ethoxy-5-(hydroxyiminomethyl)-4-vinylimidazol-1-ylmethyl]-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

: 1073549-05-9
4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: 4'-[2-ethoxy-5-(hydroxyiminomethyl)-4-vinylimidazol-1-ylmethyl]-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester; With sulfuric acid; In ethanol; Inert atmosphere; Sonication;

With palladium 10% on activated carbon; hydrogen; In ethanol; water; at 20 ℃; for 5h;
DOI:10.1021/acsmedchemlett.8b00462

Reference yield:

: 1073549-18-4
4'-[2-ethoxy-4-ethyl-5-(hydroxyiminomethyl)imidazol-1-ylmethyl]-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

: 1073549-05-9
4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: With ammonium hydroxide; hydrogen; Raney nickel; In ethanol; for 3h; under 760.051 Torr;

Reference yield:

: 1073543-60-8
tert-butyl 3'-fluoro-4'-methyl-[1,1'-biphenyl]-2-carboxylate

: 1073549-05-9
4'-(5-aminomethyl-2-ethoxy-4-ethylimidazol-1-ylmethyl)-3'-fluorobiphenyl-2-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 7 h / 90 °C / Inert atmosphere

2: sodium hydroxide / tetrabutylammomium bromide / toluene; water / 27 °C

3: caesium carbonate / palladium diacetate; catacxium A / toluene; water / 16 h / 90 °C / Inert atmosphere

4: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 24 h / 40 °C

5: hydrogen; ammonium hydroxide / Raney nickel / ethanol / 3 h / 760.05 Torr

With ammonium hydroxide; N-Bromosuccinimide; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; caesium carbonate; sodium hydroxide; dibenzoyl peroxide; tetrabutylammomium bromide; palladium diacetate; catacxium A; In tetrachloromethane; ethanol; water; toluene;