2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

Base Information

Chemical Name:2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid
CAS No.:1402150-05-3
Molecular Formula:C₂₆H₃₀F₂N₆O₅S
Molecular Weight:576.624
Hs Code.:

2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

Synonyms:2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

Suppliers and Price of 2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of 2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

There total 9 articles about 2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.87%

: 1156491-10-9
C₉H₉F₂N*ClH

: 1402150-04-2
2-((3aR,4S,6R,6aS)-6-(7-chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yloxy)acetic acid

: 1402150-05-3
2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 - 30 ℃;

Reference yield:

: 155899-66-4
(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

: 1402150-05-3
2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / water; tetrahydrofuran / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0 °C

3.1: ethanol; ammonium cerium (IV) nitrate / 50 - 70 °C

3.2: 20 - 70 °C

4.1: triethylamine / ethanol / 36 h / 125 °C / 3677.86 Torr / Autoclave; Inert atmosphere

5.1: sodium hydroxide; water / methanol / 0 - 30 °C

6.1: isopentyl nitrite / acetonitrile / 10 - 70 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

With ammonium cerium (IV) nitrate; ethanol; potassium tert-butylate; water; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 866551-95-3
ethyl 2-(6-(benzyloxycarbonylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy) acetate

: 1402150-05-3
2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium formate / palladium 10% on activated carbon / ethanol / 50 - 60 °C

1.2: 20 - 60 °C

2.1: triethylamine / ethanol / 36 h / 125 °C / 3677.86 Torr / Autoclave; Inert atmosphere

3.1: sodium hydroxide; water / methanol / 0 - 30 °C

4.1: isopentyl nitrite / acetonitrile / 10 - 70 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 25 - 30 °C

With water; ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isopentyl nitrite; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; acetonitrile;