methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

Base Information

Chemical Name:methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate
CAS No.:1402150-11-1
Molecular Formula:C₂₄H₂₈F₂N₆O₅S
Molecular Weight:550.586
Hs Code.:

methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

Synonyms:methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

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Chemical Property of methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

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Technology Process of methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

There total 15 articles about methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.23%

: 67-56-1
methanol

: 1402150-05-3
2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid

: 1402150-11-1
methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

Guidance literature:: methanol; 2-((3aR,4S,6R,6aS)-6-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)acetic acid; With hydrogenchloride; water; at 20 ℃; for 16h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 274693-53-7
[3aS-(3aα,4α,6α,6aα)]-(tetrahydro-6-hydroxy-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)carbamic acid phenylmethyl ester

: 1402150-11-1
methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 50 - 60 °C

2.2: 20 - 60 °C

3.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 35 °C

4.1: hydrogenchloride; water / 20 - 70 °C

5.1: acetic acid / methanol / 0 - 30 °C

6.1: isopentyl nitrite / acetonitrile / 30 - 60 °C

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 25 - 35 °C

With hydrogenchloride; potassium tert-butylate; water; ammonium formate; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;

Reference yield:

: 866551-95-3
ethyl 2-(6-(benzyloxycarbonylamino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy) acetate

: 1402150-11-1
methyl 2-((1S,2S,3S,4R)-4-(7-((1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,3-dihydroxycyclopentyloxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium formate / palladium 10% on activated carbon / ethanol / 50 - 60 °C

1.2: 20 - 60 °C

2.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 - 35 °C

3.1: hydrogenchloride; water / 20 - 70 °C

4.1: acetic acid / methanol / 0 - 30 °C

5.1: isopentyl nitrite / acetonitrile / 30 - 60 °C

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 25 - 35 °C

With hydrogenchloride; water; ammonium formate; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; water; acetonitrile;