(2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

Base Information

Chemical Name:(2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide
CAS No.:114530-03-9
Molecular Formula:C₃₉H₆₃N₅O₆S
Molecular Weight:730.025
Hs Code.:

(2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

Synonyms:(2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

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Chemical Property of (2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

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Technology Process of (2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

There total 14 articles about (2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 556-24-1
methyl 3-methylbutanoate

: 114530-03-9
(2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / diisopropylamine, n-butyllitium / tetrahydrofuran; hexamethylphosphoric acid triamide / 2.5 h / Ambient temperature

2: 42 percent / potassium tert-butoxide, H₂O / diethyl ether / 18 h / Ambient temperature

3: 1.) hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) DMF, 0 deg C, 3 d, 2.) 0 deg C, 2 h; room temperature, 24 h

4: 99 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 4 h / 25 °C

5: hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 1.) 0-5 deg C, 6 h, 2.) room temperature, 2 d

6: 4.0 g / 95percent trifluoroacetic acid / 0.5 h / 25 °C

7: hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide

With n-butyllithium; potassium tert-butylate; water; hydrogen; benzotriazol-1-ol; diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a027

Reference yield:

: 105852-64-0
(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

: 114530-03-9
(2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 1.) 0-5 deg C, 6 h, 2.) room temperature, 2 d

2: 4.0 g / 95percent trifluoroacetic acid / 0.5 h / 25 °C

3: hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00117a027

Reference yield:

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

: 114530-03-9
(2S,4S,5S)-5-[(S)-2-[(R)-2-Benzyl-3-(2-methyl-propane-2-sulfonyl)-propionylamino]-3-(1H-imidazol-4-yl)-propionylamino]-6-cyclohexyl-4-hydroxy-2-isopropyl-hexanoic acid butylamide

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / diisopropylamine, n-butyllitium / tetrahydrofuran; hexamethylphosphoric acid triamide / 2.5 h / Ambient temperature

2: 42 percent / potassium tert-butoxide, H₂O / diethyl ether / 18 h / Ambient temperature

3: 1.) hydroxybenzotriazole, dicyclohexylcarbodiimide / 1.) DMF, 0 deg C, 3 d, 2.) 0 deg C, 2 h; room temperature, 24 h

4: 99 percent / hydrogen / 10percent Pd-C / methanol; H₂O / 4 h / 25 °C

5: hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 1.) 0-5 deg C, 6 h, 2.) room temperature, 2 d

6: 4.0 g / 95percent trifluoroacetic acid / 0.5 h / 25 °C

7: hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide

With n-butyllithium; potassium tert-butylate; water; hydrogen; benzotriazol-1-ol; diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00117a027