tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Chemical Name:tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate
CAS No.:1301612-28-1
Molecular Formula:C₂₉H₃₀FN₃O₄
Molecular Weight:503.573
Hs Code.:

Synonyms:tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

There total 4 articles about tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 762-51-6
1-fluoro-2-iodoethane

: 1301610-60-5
tert-butyl (1-(4-(4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

: 1301612-28-1
tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

: 873306-40-2
6-iodo-5-phenyl-3H-furo[2,3-d]pyrimidin-4-one

: 1301612-28-1
tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1301612-28-1
tert-butyl 1-(4-(3-(2-fluoroethyl)-4-oxo-5-phenyl-3,4-dihydrofuro[2,3-d]pyrimidin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide;